Table 9 Expanded Genotypes Analysis results for 5 RF-scored genes identified in the Severe cohort linked to disease signatures of 2 or 3 SNPs (one disease signature contains SNPs associated with two genes)
Target Gene | SNX9 | ADIPOQ | DLC1 | NOL4 | PDE6C |
|---|---|---|---|---|---|
Universally causative minor allele | 0 | 0 | 0 | 0 | 0 |
Universally protective minor allele | 0 | 3 | 0 | 2 | 2 |
Minor allele with SNP-specific causative effect | 2 | 0 | 0 | 0 | 0 |
Minor allele with SNP-specific protective effect | 2 | 3 | 0 | 0 | 2 |
Minor allele with combination-specific causative effect | 0 | 3 | 0 | 2 | 0 |
Minor allele with combination-specific protective effect | 0 | 0 | 0 | 0 | 0 |
Ambiguous/no consistent effect | 0 | 1 | 2 | 0 | 0 |