Table 6 List of genes that were uniquely associated with the Fatigue Dominant case cohort
Gene | % Patients with corresponding disease signature in Fatigue cases (Fatigue controls) | Gene function | Mechanism of action hypothesis in long COVID |
|---|---|---|---|
ABCA9 | 74.6 (1.5) | ATP-binding cassette | Cholesterol responsive gene involved in monocyte differentiation [49] |
ACOT12 | 14.3 (1.6) | Acyl-coA thioesterase | Acetyl-coA signaling and cholesterol biosynthesis [50] |
ANKRD6 | 25.6 (1.1) | Ankyrin repeat domain 6 | Possible links to muscle function and lipid metabolism [51, 52] |
LYRM2 | 25.6 (1.1) | LYR motif containing 6 | Assembly of NADH-dehydrogenase complex, involved in cellular respiration [53] |
POR | 23.9 (2.2) | Cytochrome P450 oxidoreductase | Downstream of MAPK signaling in oxidative stress pathway [54] |
RRBP1 | 71.2 (17.6) | Ribosome binding protein 1 | Relocates to mitochondrial vicinity during mitochondrial protein import stress, involved in endurance capacity in skeletal muscle during exercise [55] |
SPTBN5 | 72.3 (1.54) | Spectrin, beta, non-erythrocytic 5 | Novel |
TNIK | 74.4 (19.1) | TRAF2 and NCK interacting kinase | Regulates JNK signaling [56] |
TNS1 | 83.2 (2.97) | Tensin 1 | Lack of AMPK increases tensin expression [57] |
TPST1 | 84.5 (2.64) | Tyrosylprotein sulfotransferase 1 | Required for monocyte recruitment [58] |