Fig. 9

Schematic representation of the working model. Acute inflammatory pain impairs sustained attention performance as measured by the 3CSRTT, while chronic inflammatory pain has no significant effect. The hyperexcitation of CaMKIIα neurons in the LPBN contributes to the acute inflammatory pain-induced impairment of sustained attention performance in 3CSRTT. Insufficient activation of CaMKIIα neurons in the LPBN is correlated with the recovery of performance on the sustained-attention task during chronic inflammatory pain