Fig. 2

The effect of CFA-induced inflammatory pain on 3CSRTT performance. A Schematic of CFA paw injection. B Withdrawal latency of the ipsilateral hind paws after saline or CFA injection (n = 8 mice per group). C Experimental design. The 3-CSRTT training (50 trials per day) was performed from Day -28 to Day -2 and the 3-CSRTT testing was performed from Day -1 (baseline) to Day 22. CFA was injected on Day 0. D–I Effects of saline or CFA injection on correct rate (D), omission rate (E), incorrect rate (F), premature rate (G), correct response latency (H) and reward latency (I) in the 3CSRTT. Data are mean ± SEM. *p < 0.05, ***p < 0.001. Two-way ANOVA followed by the Sidak’ s multiple comparisons test