Fig. 6

Effects of hypoxic or normoxic-stimulated ADSCs on wound healing in nude mice. The skin wound healing nude mice model was prepared and divided into 3 groups (N = 6 per group): spontaneous healing group (model control group); normoxia-ADSCs group (model mice were treated with normoxia-ADSCs); hypoxia-ADSCs group (model mice were treated with hypoxia-ADSCs). A skin wounds on days 1, 5, and 10 after wound puncture were exhibited, and then the percentage of wound area was calculated. B H&E staining was used to detect the pathological damage in wounded skin. C IHC staining was applied to detect CD31 expression in wounded skin. **p < 0.01, compared with spontaneous healing group; ##p < 0.01, compared with normoxia-ADSCs group