Fig. 4

Detailed analysis of cell subpopulation communication and overarching cellular communication patterns. A Communication frequency and intensity among cell subpopulations; B 2D representation of primary emitters and receivers; C-D Key outgoing and incoming signal patterns; E Estimation of output pattern count using Cophenetic and Silhouette metrics; F Cell subpopulations and associated signaling pathways for output patterns; G River plot of secretion cell outgoing signal trends; H Estimation of input pattern count using Cophenetic and Silhouette metrics; I Cell subpopulations and associated signaling pathways for input patterns; J River plot depicting secretion cell incoming signal trends