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Fig. 11 | Journal of Translational Medicine

Fig. 11

From: Spatiotemporal evolution of AML immune microenvironment remodeling and RNF149-driven drug resistance through single-cell multidimensional analysis

Fig. 11

Intracellular localization of RNF149 and its function in AML drug-resistant cells. A Immunofluorescence demonstrates the presence of RNF149 in both AML and drug-resistant cells, with nuclei stained using DAPI (scale bar: 20 μm); B Efficiency of RNF149 knockdown is verified in MOLM13/R and MV4-11/R cells. Subsequent assays include CCK-8 C, colony formation D, and flow cytometry for apoptosis detection E to ascertain the role of RNF149 in AML drug-resistant cells. Data are represented as mean ± SD (n = 3), with intergroup comparisons indicated as: * p < 0.05, ** p < 0.01, and *** p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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