Fig. 7

The altered expression of FABP5 promotes proliferation, migration, and lipid metabolism of QGP-1 cells. A Representative images of FABP5 immunohistochemistry staining in pNENs samples were shown. B, C The knockdown and overexpression rate of FABP5 was detected by western blotting. D–J FABP5 knockdown inhibited the growth of pNENs, indicated by the results of CCK-8 (D, E), colony formation (F, G), and EdU (H–K) assays in QGP-1 cells with FABP5 knockdown and overexpression, Edu magnification: ×200. L–O The transwell analysis was conducted to examine the effect of FABP5 knockdown on the migration and invasion capabilities of QGP-1 cells, magnification: ×100. P LDs (lipid droplets) were detected using Nile red in QGP-1 cells with FABP5 knockdown and overexpression, along with the results of relative fluorescence intensity, magnification: ×200. Q–S The relative amounts of free fatty acids, triglycerides, and cholesterol were measured in QGP-1 cells with FABP5 knockdown. *p < 0.01, **p < 0.01, ***p < 0.001, ****p < 0.0001