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Table 2 Linear regression analysis using FRS, AAA-1 or ALP as dependent variables in PREVEND participants

From: Antibody against apolipoprotein-A1, non-alcoholic fatty liver disease and cardiovascular risk: a translational study

Variable

Univariate analysis

Multivariate analysis

β (95% CI)

P-value

β (95% CI)

P-value

PREVEND participants (n = 312)

 FRS

  AAA-1

0.30 (0.08–0.53)

0.007

0.20 (0.01–0.39)

0.034

  ALP

0.97 (0.71–1.23)

 < 0.001

0.60 (0.35–0.85)

 < 0.001

  FLI

0.41 (0.33–0.49)

 < 0.001

0.34 (0.26–0.42)

 < 0.001

 AAA-1

  FLI

0.01 (− 0.02–0.06)

0.452

− 0.02 (− 0.07–0.02)

0.346

  ALP

0.16 (0.02–0.30)

0.012

0.11 (− 0.03–0.26)

0.126

  FRS

0.07 (0.02–0.13)

0.007

0.07 (0.006–0.13)

0.032

 FLI

  AAA-1

0.1 (− 0.17–3.73)

0.452

− 0.11 (− 0.35–0.12)

0.345

  ALP

0.98 (0.66–1.31)

 < 0.001

0.44 (0.12–0.76)

0.006

  FRS

0.61 (0.5–0.73)

0.001

0.55 (0.43–0.68)

 < 0.001

 ALP

  AAA-1

0.1 (0.01–0.19)

0.011

–

–

FLI ≥ 60 PREVEND participants (n = 112)

 FRS

  AAA-1

0.37 (0.008–0.74)

0.040

0.25 (− 0.11–0.63)

0.177

  FLI

1.2 (0.42–2.08)

0.003

1.1 (0.28–1.94)

0.008

  ALP

0.43 (0.02–0.83)

0.032

0.26 (− 0.15–0.67)

0.215

 AAA-1

  FRS

0.09 (0.004–0.37)

0.041

0.06 (− 0.03–0.16)

0.172

  FLI

0.20 (− 0.22–0.63)

0.346

0.02 (− 0.4–0.46)

0.891

  ALP

0.34 (0.14–0.53)

0.001

0.30 (0.10–0.51)

0.003

 FLI

  AAA-1

0.03 (− 0.04–0.12)

0.346

0.005 (− 0.07–0.09)

0.895

  ALP

0.07 (− 0.01–0.15)

0.123

0.04 (− 0.04–0.13)

0.323

  FRS

0.06 (0.02–0.1)

0.001

0.05 (0.01–0.09)

0.008

 ALP

  AAA-1

0.28 (0.12–0.45)

0.001

–

–

FLI < 60 PREVEND participants (n = 200)

 FRS

  AAA-1

0.31 (0.06–0.57)

0.015

0.22 (− 0.002–0.44)

0.053

  ALP

0.99 (0.68–1.31)

 < 0.001

0.75 (0.44–1.06)

 < 0.001

  FLI

0.37 (0.25–0.48)

 < 0.001

0.27 (0.15–0.39)

 < 0.001

 AAA-1

  FRS

0.09 (0.01–0.16)

0.018

0.08 (− 0.001–0.17)

0.051

  FLI

0.04 (− 0.02–0.11)

0.187

0.01 (− 0.06–0.09)

0.681

  ALP

0.10 (− 0.03–0.29)

0.271

0.06 (− 0.1–0.21)

0.955

 FLI

  AAA-1

0.18 (− 0.08–0.46)

0.189

0.05 (− 0.2–0.31)

0.687

  ALP

0.79 (0.43–1.14)

 < 0.001

0.41 (0.04–0.78)

0.022

  FRS

0.43 (0.29–0.57)

 < 0.001

0.36 (0.2–0.51)

 < 0.001

 ALP

  AAA-1

0.05 (− 0.04–0.16)

0.201

–

–

  1. Î’ unstandardized regression coefficient; CI, confidence interval; AAA-1, anti-apolipoprotein A-1; ALP, alkaline phosphatase; FRS, Framingham risk score; FLI, fatty liver index. Because the non-normal distribution of all variables, data were transformed in logarithmic value
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Journal of Translational Medicine

ISSN: 1479-5876

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