Antibody against apolipoprotein-A1, non-alcoholic fatty liver disease and cardiovascular risk: a translational study

Pagano, Sabrina; Bakker, Stephan J. L.; Juillard, Catherine; Vossio, Stefania; Moreau, Dimitri; Brandt, Karim J.; Mach, François; Dullaart, Robin P. F.; Vuilleumier, Nicolas

doi:10.1186/s12967-023-04569-7

Table 1 Spearman’s rank correlation between levels of AAA-1, FLI, FRS and clinical characteristics of PREVEND participants

From: Antibody against apolipoprotein-A1, non-alcoholic fatty liver disease and cardiovascular risk: a translational study

Variable	AAA-1		FLI		FRS
Variable	R	P	R	P	R	P
PREVEND participants (n = 312)
Age	0.06	0.272	0.35	< 0.001	0.72	< 0.001
Waist circumference	0.004	0.931	0.91	< 0.001	0.42	< 0.001
Weight	0.007	0.893	0.79	< 0.001	0.19	0.001
BMI	0.03	0.223	0.84	< 0.001	0.38	< 0.001
Systolic blood pressure	0.02	0.745	0.47	< 0.001	0.61	< 0.001
Diastolic blood pressure	0.02	0.735	0.38	< 0.001	0.38	< 0.001
Total-c	− 0.03	0.502	0.09	0.102	0.22	< 0.001
LDL-c	− 0.03	0.552	0.06	0.271	0.21	0.001
HDL-c	− 0.09	0.103	− 0.5	< 0.001	− 0.30	< 0.001
TG	0.02	0.619	0.65	< 0.001	0.40	< 0.001
Plasma glucose	0.10	0.073	0.42	< 0.001	0.31	< 0.001
ALP	0.09	0.081	0.30	< 0.001	0.38	< 0.001
ALT	− 0.008	0.885	0.37	< 0.001	0.17	0.001
AST	0.10	0.051	0.28	< 0.001	0.21	0.001
GGT	0.07	0.211	0.67	< 0.001	0.33	< 0.001
AAA-1	–	–	0.04	0.461	0.11	0.041
FLI	0.04	0.464	–	–	0.49	< 0.001
FRS	0.11	0.042	0.49	< 0.001	–	–
FLI ≥ 60 PREVEND participants (n = 112)
Age	0.002	0.982	0.17	0.065	0.64	< 0.001
Waist circumference	0.01	0.866	0.66	< 0.001	0.11	0.232
Weight	0.02	0.837	0.46	< 0.001	− 0.23	0.015
BMI	0.01	0.867	0.56	< 0.001	0.07	0.455
Systolic blood pressure	− 0.01	0.801	0.25	0.005	0.49	< 0.001
Diastolic blood pressure	− 0.03	0.711	0.11	0.252	0.08	0.394
Total-c	0.005	0.956	0.05	0.531	0.03	0.688
LDL-c	0.03	0.717	0.009	0.921	− 0.005	0.955
HDL-c	− 0.26	0.004	− 0.08	0.362	− 0.05	0.582
TG	0.09	0.308	0.28	0.002	0.26	0.004
Plasma glucose	0.1	0.233	0.13	0.175	0.35	0.001
ALP	0.3	0.003	0.14	0.137	0.17	0.072
ALT	0.02	0.813	0.24	0.012	0.11	0.231
AST	0.05	0.582	0.09	0.312	0.005	0.952
GGT	0.09	0.293	0.43	< 0.001	0.04	0.642
AAA-1	–	–	0.09	0.294	0.21	0.021
FLI	0.09	0.293	–	–	0.27	0.003
FRS	0.21	0.023	0.27	0.003	–	–
FLI < 60 PREVEND participants (n = 200)
Age	0.08	0.262	0.27	< 0.001	0.70	< 0.001
Waist circumference	0.02	0.712	0.84	< 0.001	0.29	< 0.001
Weight	0.03	0.599	0.65	< 0.001	0.006	0.922
BMI	0.08	0.227	0.70	< 0.001	0.24	0.001
Systolic blood pressure	0.05	0.425	0.32	< 0.001	0.54	< 0.001
Diastolic blood pressure	0.06	0.385	0.30	< 0.001	0.39	< 0.001
Total-c	0.05	0.434	0.20	0.004	0.36	< 0.001
LDL-c	− 0.06	0.382	0.23	0.001	0.39	< 0.001
HDL-c	− 0.04	0.495	− 0.41	< 0.001	− 0.19	0.004
TG	0.01	0.853	0.5	< 0.001	0.23	0.001
Plasma glucose	0.07	0.265	0.22	0.001	0.13	0.050
ALP	0.02	0.723	0.31	< 0.001	0.41	< 0.001
ALT	− 0.009	0.891	0.22	0.001	0.04	0.514
AST	0.16	0.015	0.29	< 0.001	0.24	0.001
GGT	0.09	0.174	0.52	< 0.001	0.22	0.001
AAA-1	–	–	0.09	0.185	0.11	0.102
FLI	0.09	0.182	–	–	0.37	< 0.001
FRS	0.11	0.101	0.37	< 0.001	–	–

Total-c total cholesterol, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol, TG triglycerides, BMI body mass index, ALT alanine transaminase, AST aspartate transaminase, FLI fatty liver index, ALP alkaline phosphatase, GGT gamma-glutamyl-transferase, FRS Framingham risk score, AAA-1 anti-apolipoprotein A-1 IgG

Back to article page

ISSN: 1479-5876

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com

Journal of Translational Medicine

Contact us