Table 3 Colocalization results in the target gene region of sulfonylureas for blood glucose and stroke in validation study
From: Genetically proxied antidiabetic drugs targets and stroke risk
Drug class | Stroke | Gene | PP.H0 | PP.H1 | PP.H2 | PP.H3 | PP.H4 |
|---|---|---|---|---|---|---|---|
Sulfonylureas | Any stroke | KCNJ11 | 4.5e−03 | 3.0e−04 | 2.21e−01 | 1.45e−02 | 0.760 |
ABCC8 | 4.5e−03 | 3.0e−04 | 2.21e−01 | 1.49e−02 | 0.759 | ||
Sulfonylureas | Any ischemic stroke | KCNJ11 | 5.0e−03 | 4.0e−04 | 2.66e−01 | 2.0e−02 | 0.708 |
ABCC8 | 5.0e−03 | 4.0e−04 | 2.66e−01 | 2.1e−02 | 0.707 |