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Table 2 Colocalization results in the target gene region of sulfonylureas for blood glucose and stroke

From: Genetically proxied antidiabetic drugs targets and stroke risk

Drug class

Stroke

Gene

PP.H0

PP.H1

PP.H2

PP.H3

PP.H4

Sulfonylureas

Any stroke

KCNJ11

1.40e−07

5.19e−09

2.08e−01

6.92e−03

0.785

ABCC8

3.09e−07

5.93e−09

2.57e−01

4.20e−03

0.739

Sulfonylureas

Any ischemic stroke

KCNJ11

1.62e−07

6.73e−09

2.41e−01

9.25e−03

0.750

ABCC8

3.22e−07

6.15e−09

2.68e−01

4.40e−03

0.728

  1. The region was defined as ± 2.5 kb of gene region
  2. PP indicates posterior probability
  3. H0: neither trait has a genetic association in the region
  4. H1: only stroke has a genetic association in the region
  5. H2: only blood glucose has a genetic association in the region
  6. H3: both traits are associated, but with different causal variants
  7. H4: both traits are associated and share a single causal variant
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Journal of Translational Medicine

ISSN: 1479-5876

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