Fig. 8
From: Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling
Attenuation of hepatic IR injury by liver-targeted G6P supplement by nanoparticle delivery system. A Chemical structure and the synthesis process of G6P nanoparticle. B Ex vivo bioimaging and normalized DiD-fluorescent intensity in the main organs (n = 3) of the mice IV injected with DiD-loaded PEG-Lipids/ERP/G6P (DiD, 0.75 mg/kg), and dissected and imaged at 2, 6, 12, 24, 48, or 72 h post-injection. C Serum levels of ALT and AST (n = 5/group). D Serum inflammatory cytokines (n = 5/group). E, F Hepatic mRNA levels of inflammatory factors (n = 4/group) and expression of apoptosis-related proteins (n = 2/group). G–H Liver necrosis, apoptosis and inflammatory cells enrichment in liver sections (n = 3/group). All data are shown as means ± SDs. ns indicates no significance between the two indicated groups; *p < 0.05; **p < 0.01