Fig. 5
From: Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling
Transcriptome, proteome, and metabolome network analysis reveals disturbed pathways in Insig2 overexpression mice relative to those in WT controls subjected to IR injury. A Hierarchical clustering heat map showing the distribution profiles of RNA-seq (n = 3/group). B Volcano plots indicating DEGs (red, up-regulated genes; blue, down-regulated genes). C Major biological pathways contributing to Insig2 function based on KEGG enrichment analysis of RNA-seq. D Hierarchical clustering heat map showing the distribution profiles of proteomics (n = 3/group). E Volcano plots indicating DEPs (red, up-regulated proteins; blue, down-regulated proteins. F Major biological pathways contributing to Insig2 function based on KEGG enrichment analysis of proteomics. G Hierarchical clustering heat map showing all detected DEMs (n = 6/group). H OPLS-DA image showing global sample distribution profiles. I Pathway-based analysis of metabolic changes