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Table 2 Clinical characteristics of patients and laboratory findings

From: Clinical evaluation of metagenomic next-generation sequencing in unbiased pathogen diagnosis of urinary tract infection

 

Culture positive(n = 148)

Culture negative (n = 65)

P value

Age, median (IQR), years

75 (64–84)

62.5 (56.75–74)

 < 0.0001a

Gender, n (%)

 Male

75 (50.68)

42 (64.62)

0.0597b

 Female

73 (49.32)

23 (35.38)

0.0597b

Comorbidities, n (%)

 Diabetes

4 (2.70)

4 (6.15)

0.2225b

 Pulmonary disease

18 (12.16)

4 (6.15)

0.1846b

 Cardiovascular disease

5 (3.38)

3 (4.62)

0.6619b

 Cerebrovascular disease

9 (6.08)

3 (4.62)

0.6692b

 Malignancy

27 (18.24)

12 (18.46)

0.9697b

 Chronic renal disease

9 (6.08)

15 (23.08)

0.0003b

 Chronic liver disease

10 (6.76)

3 (4.62)

0.5477b

 Haematological disease

4 (2.70)

2 (3.08)

0.8792b

 Hospital, median (IQR), days

25.50 (15–63.5)

12.50 (7.75–25)

 < 0.0001a

 Catheterized, n (%)

106 (71.62)

29 (44.62)

0.0002b

 WBC count, (RR, 0–30), /μL

143.80 (1.3–32,444.8)

12.60 (1–4544.9)

 < 0.0001a

 Unknown

34 (22.97)

1 (1.54)

 < 0.0001c

 0–30

22 (14.87)

42 (64.61)

  > 30

92 (62.16)

22 (33.85)

PON, (RR, 40–75)

76.75 (1.1–95.3)

71.10 (30.9–95.8)

0.0944a

 Unknown

38 (25.67)

2 (3.08)

 < 0.0500c

  < 40%

3 (2.03)

1 (1.54)

 40–75%

49 (33.11)

40 (61.54)

  > 75%

58 (39.19)

22 (33.84)

CRP, (RR, < 10), mg/L

18.05 (0.04–232.8)

23.20 (0.5–275.9)

0.2971a

 Unknown

43 (29.05)

4 (6.15)

 > 0.0500c

  < 10

42 (28.38)

24 (36.92)

 10–50

31 (20.95)

14 (21.54)

  > 50

32 (21.62)

23 (35.39)

PCT, (RR, < 0.05), ng/mL

0.2170 (0.02–14.95)

0.2000 (0.02–17.11)

0.4738a

 Unknown

64 (43.24)

38 (58.46)

 > 0.0500c

  < 0.05

11 (7.43)

4 (6.15)

  > 0.05

73 (49.33)

23 (35.39)

  1. Bolded p-values indicate significant values (p < 0.0500)
  2. IQR, interquartile range; WBC, white blood cells; PON, percentage of neutrophils; CRP, C-reactive protein; PCT, procalcitonin; RR, reference range
  3. asignificance was determined by Mann–Whitney test
  4. bsignificance was determined by Chi-square test
  5. csignificance was determined by Fisher’s exact test