Table 7 Biochemical parameters (mean ± SD) at enrolling visit (week -4) and week 8 in VLCKD and HBD group
| Â | VLCKsD | HBD | F, p-value |
|---|---|---|---|
WBC | |||
 Week -4 | 6.60 ± 1.41 | 6.22 ± 6.01 | F = 1.544, 0.221 |
 Week 8 | 5.93 ± 1.25 | 6.01 ± 1.58 | |
 Δ | − 0.67 ± 1.00* p = 0.001 | − 0.21 ± 1.48 | |
Hematocrit | |||
 Week -4 | 42.3 ± 8.97 | 41.54 ± 3.43 | F = 0.053, 0.818 |
 Week 8 | 41.47 ± 2.46 | 41.27 ± 4.06 | |
 Δ | − 0.84 ± 9.69 | -0.26 ± 2.67 | |
PLT | |||
 Week -4 | 278.54 ± 75.38 | 242.37 ± 62.41 | F = 0.018, 0.895 |
 Week 8 | 251.03 ± 65.96 | 237.31 ± 58.96 | |
 Δ | − 27.5 ± 46.23* p = 0.004 | − 5.06 ± 16.60 | |
Neutrophils | |||
 Week -4 | 3.88 ± 1.04 | 3.62 ± 1.21 | F = 0.728, 0.398 |
 Week 8 | 3.40 ± 0.87 | 3.38 ± 1.19 | |
 Δ | -0.48 ± 0.73* p = 0.002 | − 0.24 ± 1.15 | |
Lymphocytes | |||
 Week -4 | 2.11 ± 0.44 | 2.08 ± 0.46 | F = 1.096, 0.301 |
 Week 8 | 2.03 ± 0.44 | 2.11 ± 0.41 | |
 Δ | − 0.08 ± 0.36 | 0.03 ± 0.33 | |
Monocytes | |||
 Week -4 | 0.39 ± 0.14 | 0.35 ± 0.11 | F = 2.701, 0.108 |
 Week 8 | 0.31 ± 0.13 | 0.33 ± 0.10 | |
 Δ | − 0.08 ± 0.10* p < 0.001 | − 0.02 ± 0.13 | |
Glycemia | |||
 Week -4 | 99.11 ± 8.64 | 96.00 ± 11.03 | F = 1.041, 0.313 |
 Week 8 | 96.78 ± 9.34 | 96.59 ± .7.92 | |
 Δ | − 2.32 ± 8.38 | 0.59 ± 10.61 | |
AST | |||
 Week -4 | 18.28 ± 6.54 | 19.76 ± 5.59 | F = 1.048, 0.312 |
 Week 8 | 19.11 ± 6.52 | 18.29 ± 6.60 | |
 Δ | 0.82 ± 7.14 | − 1.12 ± 3.97 | |
ALT | |||
 Week -4 | 20.64 ± 11.87 | 23.29 ± 13.64 | F = 2.332, 0.134 |
 Week 8 | 21.28 ± 12.97 | 18.29 ± 6.60 | |
 Δ | 0.64 ± 13.60 | − 5.00 ± 8.71* p = 0.031 | |
GGT | |||
 Week -4 | 22.50 ± 13.22 | 19.00 ± 7.66 | F = 1.475, 0.231 |
 Week 8 | 18.28 ± 12.08 | 17.23 ± 6.01 | |
 Δ | − 4.21 ± 7.29* p = 0.005 | − 1.77 ± 5.08 | |
Creatinine | |||
 Week -4 | 0.69 ± 0.11 | 0.72 ± 0.12 | F = 0.943, 0.337 |
 Week 8 | 0.69 ± 0.09 | 0.74 ± 0.13 | |
 Δ | − 0.003 ± 0.12 | 0.03 ± 0.08 | |
Uric acid | |||
 Week -4 | 4.32 ± 1.35 | 4.52 ± 0.80 | F = 0.443, 0.509 |
 Week 8 | 4.50 ± 1.14 | 4.50 ± 0.77 | |
 Δ | 0.17 ± 1.16 | − 0.01 ± 0.41 | |
CRP | |||
 Week -4 | 4.91 ± 5.89 | 3.63 ± 2.80 | F = 1.090, 0.302 |
  Week -8 | 3.56 ± 4.60 | 4.39 ± 8.94 | |
 Δ | − 1.34 ± 3.78 | 0.75 ± 9.53 | |
NLR | |||
 Week -4 | 1.87 ± 0.56 | 1.75 ± 0.47 | F = 0.002, 0.964 |
 Week 8 | 1.71 ± 0.51 | 1.59 ± 0.47 | |
 Δ | − 0.17 ± 0.43 | − 0.16 ± 0.48 | |
PLR | |||
 Week -4 | 136.74 ± 43.67 | 120.97 ± 38.23 | F = 0.158, 0.693 |
 Week 8 | 128.18 ± 41.11 | 116.15 ± 35.16 | |
 Δ | -8.55 ± 33.62 | -4.82 ± 21.92 | |
CD3 + T lymphocytes | |||
 Week -4 | 62.04 ± 13.65 | 63.80 ± 10.20 | F = 0.000, 0.992 |
 Week 8 | 66.83 ± 12.70 | 68.53 ± 10.91 | |
 Δ | 4.79 ± 18.57 | 4.73 ± 9.89 | |
CD4 + T lymphocytes | |||
 Week -4 | 60.00 ± 11.91 | 64.60 ± 13.94 | F = 0.224, 0.639 |
 Week 8 | 63.04 ± 15.90 | 64.87 ± 13.03 | |
 Δ | 3.0419.37 | 0.27 ± 14.90 | |
CD8 + T lymphocytes | |||
 Week -4 | 29.95 ± 10.36 | 26.20 ± 10.52 | F = 1.083, 0.305 |
 Week 8 | 27.58 ± 12.61 | 28.47 ± 10.68 | |
 Δ | − 2.37 ± 14.39 | 2.26 ± 12.03 | |
CD19 + B lymphocytes | |||
 Week -4 | 18.77 ± 10.13 | 16.87 ± 9.98 | F = 0.020, 0.888 |
 Week 8 | 15.02 ± 12.16 | 12.47 ± 8.88 | |
 Δ | − 3.75 ± 15.27 | − 4.40 ± 11.53 | |
CD3- CD16 + CD56 + NK cells | |||
 Week -4 | 15.80 ± 10.94 | 15.73 ± 7.33 | F = 0.758, 0.390 |
 Week 8 | 13.94 ± 7.47 | 17.67 ± 10.22 | |
 Δ | − 1.86 ± 14.15 | 1.93 ± 11.83 | |
Naïve CD4 + T lymphocytes | |||
 Week -4 | 22.20 ± 14.24 | 20.0 ± 9.21 | F = 0.012, 0.912 |
 Week 8 | 26.45 ± 14.21 | 23.60 ± 11.47 | |
 Δ | 4.24 ± 18.69 | 3.60 ± 15.65 | |
Naïve CD8 + T lymphocytes | |||
 Week -4 | 30.30 ± 15.66 | 25.13 ± 13.67 | F = 0.478, 0.494 |
 Week 8 | 30.77 ± 14.21 | 30.62 ± 13.23 | |
 Δ | 0.47 ± 22.52 | 5.49 ± 21.24 | |
Regulatory T cells | |||
 Week -4 | 1.01 ± 1.20 | 1.08 ± 1.41 | F = 1.891, 0.178 |
 Week 8 | 1.12 ± 1.20 | 0.40 ± 0.50 | |
 Δ | 0.10 ± 1.75 | − 0.68 ± 1.59 | |
Th17 lymphocytes | |||
 Week -4 | 0.32 ± 0.31 | 0.27 ± 0.24 | F = 2.262, 0.150 |
 Week 8 | 0.22 ± 0.21 | 0.50 ± 0.64 | |
 Δ | − 0.10 ± 0.41 | 0.23 ± 0.55 | |