Fig. 5

Results of the reverse MR analysis. A The volcano plot illustrates the effect of periodontitis on genetically predicted composition of 196 gut microbiota. The X-axis represents the beta-value, the Y-axis represents the logarithmic p-value with a base of 10, P < 0.05 is considered as statistically significant. Red and green triangle points represent the microbial genera up and down regulated by periodontitis, respectively. B The lollipop plot further depicts six statistically significant intestinal microbial genera by p-value rank, the size of the points represents the number of SNPs, and the color of the points represents the beta-value. IVW inverse-variance weighted, SNP single nucleotide polymorphism