Circulating miR-133a-3p defines a low-risk subphenotype in patients with heart failure and central sleep apnea: a decision tree machine learning approach

Table 4 Prognostic value of circulating microRNAs on top of clinical models

Subgroup	miRNA	C-index (95% CI)		Improvement in c-index		Reclassification indexes at 2 years
Subgroup	miRNA	Clinical model 1	Clinical model 1 + miRNA	Δc-index (95% CI)	p-value	cNRI (95% CI)	p-value	IDI (95% CI)	p-value
Model 1	miR-133a-3p	0.568 (0.534–0.602)	0.597 (0.562–0.631)	0.029 (0.005; 0.052)	0.016	0.277 (0.036; 0.436)	0.014	0.020 (0.004; 0.044)	0.002
Model 1	miR-501-3p	0.574 (0.539–0.609)	0.577 (0.542–0.612)	0.003 (− 0.002; 0.007)	0.21	0.085 (− 0.136; 0.246)	0.42	0.001 (− 0.001; 0.010)	0.37
Model 2	miR-133a-3p	0.678 (0.647—0.709)	0.685 (0.654—0.716)	0.007 (− 0.003; 0.016)	0.17	0.230 (0.022; 0.416)	0.024	0.015 (0.001; 0.037)	0.016
Model 2	miR-501-3p	0.682 (0.650–0.714)	0.686 (0.653–0.718)	0.004 (− 0.003; 0.011)	0.29	0.079 (− 0.100; 0.291)	0.23	0.008 (− 0.000; 0.025)	0.086
Model 3	miR-133a-3p	0.731 (0.703–0.759)	0.734 (0.706–0.761)	0.003 (− 0.002; 0.007)	0.25	0.162 (− 0.195; 0.345)	0.25	0.003 (− 0.002; 0.015)	0.33
Model 3	miR-501-3p	0.736 (0.708–0.765)	0.737 (0.708–0.766)	0.001 (− 0.002; 0.003)	0.52	0.089 (− 0.265; 0.304)	0.39	0.001 (− 0.001; 0.009)	0.37

Bold values indicate the statistically significant results
CI confidence interval, cNRI continuous net reclassification improvement, IDI integrated discrimination improvement
^aModel 1 included ASV, age and sex
^bModel 2 included variables of model 1 and SBP < 120 mmHg, diabetes, diuretic, atrial fibrillation, cardiac device and 6-min walk distance
^cModel 3 included variables of model 2 and log(NT-proBNP)

ISSN: 1479-5876