Fig. 5From: Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advancesMechanisms of radiation-induced fibrosis in various tissues. Ionizing radiation causes fibrosis in the lungs, heart, skin, liver, kidney and intestine by modualting a variety of molecules involved in cytokine signaling, collagen biosynthesis, oxidative stress response and epigenetic regulation. (Figure was created with https://www.Biorender.com)Back to article page