Fig. 1From: Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapyUnmodified IVT mRNAs can trigger an immune response in the body. Unmodified mRNAs have high immunogenicity that induces interferon production through activating TLR3, TLR7, and TLR8. However, in vitro modifications of mRNAs can reduce their immunogenicity to avoid the risk of triggering an immune storm in the organismBack to article page