Fig. 6

Effect of CpG-ODNs regulating PARP1/XRCC1 signaling axis on RKI mice. A Serum BUN and creatinine levels in RKI mice in response to CpG-ODN2006 alone or combined with oe-PARP1 or oe-XRCC1 detected by an automatic biochemical analyzer. B HE staining to observe the pathological changes in the kidney tissue in RKI mice in response to CpG-ODN2006 alone or combined with oe-PARP1 or oe-XRCC1. C TUNEL to detect the level of apoptosis in the kidney tissue in RKI mice in response to CpG-ODN2006 alone or combined with oe-PARP1 or oe-XRCC1. Brown-grey color represents apoptotic cells. D ELISA detection of DNA damage index (8-OHdG) in serum of RKI mice in response to CpG-ODN2006 alone or combined with oe-PARP1 or oe-XRCC1. E ELISA detection of levels of oxidative stress-related factors (SOD, CAT, GSH, and GPx) in serum of RKI mice in response to CpG-ODN2006 alone or combined with oe-PARP1 or oe-XRCC1. F ELISA detection of MDA levels in serum of RKI mice in response to CpG-ODN2006 alone or combined with oe-PARP1 or oe-XRCC1. * P < 0.05 versus RKI mice treated with saline + oe-NC. # P < 0.05 versus RKI mice treated with ODN2006 + oe-NC. n = 8 mice for each treatment