Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanisms

Table 2 The regulation of USP12 and immunity-related pathophysiology

Pathophysiology	Target	Mechanism	Effect	References
T cells	LAT/Trat1	Deubiquitinate and stabilize LAT and Trat1	Stabilize TCR complex on the T cell surface during signaling	[45]
Macrophages	IkBα/Sp1	Activate NF-κB pathway via regulating IκBα	Affect LPS-induced macrophages response	[49]
Inflammation	NLRP3	Promote NF-κB to enhance NLRP3 inflammatory microsome activation	Promote NLRP3-mediated inflammatory response	[98, 99]
Viral infection	STAT1	Regulate various cytokines like TNF, IFN, IL	Inhibit viral infection	[102]

ISSN: 1479-5876