Fig. 2

The structure of USP12 and related complexes. A The crystal structure of free USP12 with Thumb (cyan), Palm (brown), Fingers (yellow), and Pinky Finger (green). The Pinky Finger is separated from other finger domains and possesses a kind of coiled structure that may endow USP12 with more plasticity to exert its functions. B The crystal structure of free USP46 has a high similarity with USP12. C The crystal structure of free UAF1/WDR48. D The structure of the UAF1-USP12 complex. E The structure of UAF1-WDR20-USP12 complex