Fig. 4

AC142119.1 contributes to the tumorigenesis and progression of NB in vivo. A, D Images of xenograft tumors derived from the AC142119.1 overexpression (A) or knockdown (D) models. B, E Tumor volume was measured once a week. C, F The tumors were weighed after resection. G, H The expression of AC142119.1 (G) and MYCN (H) in xenograft tumors was evaluated by qRT-PCR. I IHC staining to examine the protein level of MYCN in xenograft tumors. Scale bar, 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001