Fig. 5

Transmission electron microscopic view of the mice heart on D30. Ho, homozygous(n = 10); He, heterozygous(n = 10); WT, wild type(n = 10); Mf, myofibril; Mi, mitochondria; N, nucleus. It can be seen from the figure that the field of view of Ho was confused (A), no clear Mf structure was observed, the intracellular organelles were blurred, the nucleus (B) was irregular in shape, the nuclear membrane was discontinuous and smooth, the nucleoli were enlarged, and euchromatin was reduced; mitochondria (C) were significantly proliferated and abnormal; The He sample showed that Mf was less neatly arranged and heterochromatin was increased (B)