Fig. 1

A TSNE of different types of immune cells, with each cell color coded for its sample type of origin based on the transcript features. B The TSNE plot of immune cells within the tumor microenvironment in patients with non-NAC and NAC treatment. C The proportion of immune cells in SCLC patients with non-NAC and NAC treatment. D Multiplex immunofluorescence images of T cell infiltration in paired pre-NAC and post-NAC specimens of SCLC. E Multiplex immunofluorescence images of B cell and macrophage infiltration in paired pre-NAC and post-NAC specimens of SCLC. F Comparison of CD8 + GZMB + T cell infiltration in paired pre-NAC and post-NAC PBMC of SCLC, as detected by flow cytometry. G Comparison of Ki67 + CD3 + T cell infiltration in paired pre-NAC and post-NAC PBMC of SCLC, as detected by flow cytometry. H Comparison of B cell infiltration in pre-NAC and post-NAC PBMC of SCLC, as detected by flow cytometry. I Comparison of macrophage infiltration in PBMC pre-NAC and post-NAC SCLC, as detected by flow cytometry. J Comparison of serum GZMB in pre-NAC and post-NAC of SCLC, as detected by ELISA