Table 2 Colocalization and phenotype scanning of 13 plasma proteins with cancers
From: Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers
Cancers | Proteins | SNP | Colocalization analysis (PPH4) | Previously reported associations |
|---|---|---|---|---|
Prostate cancer | KDELC2 | rs74911261 | 9.99E−01 | Breast cancer |
Renal cell carcinoma | ||||
Leiomyoma of uterus | ||||
Blood cell traits | ||||
Impedance of the body | ||||
GSTP1 | rs1695 | 5.71E−01 | Height | |
Blood cell traits | ||||
SPINT2 | rs71354995 | 1.26E−25 | NA | |
TNFRSF10B | rs4871844 | 6.01E−03 | NA | |
CTSS | rs41271951 | 1.12E−04 | Blood protein levels | |
Breast cancer | CPNE1 | rs12481228 | 8.80E−01 | Impedance of the body |
Height | ||||
Weight | ||||
Basal metabolic rate | ||||
ISLR2 | rs2959011 | 4.20E−01 | Hypertension | |
PDIA3 | rs3110081 | 1.07E−02 | NA | |
GDI2 | rs2890364 | 1.83E−01 | NA | |
CTSF | rs1791679 | 4.93E−05 | NA | |
Lung cancer | SFTPB | rs1130866 | 9.51E−01 | Granulysin |
ICAM5 | rs281439 | 3.68E−02 | Lymphocyte count | |
Intercellular adhesion molecule 1 | ||||
FLRT3 | rs11908097 | 3.18E−01 | NA |