Table 1 Comparison of medical history risk factors, imaging features and clinicopathological characteristics between Chinese patients with high versus low risk of 70-gene signature test
Clinicopathological and imaging characteristics | 70-gene high risk = N = 62 (%) | 70-gene low risk N = 88 (%) | P-value |
|---|---|---|---|
70-gene score (Mean ± SD) | − 0.282 ± 0.234 | 0.226 ± 0.153 |  < 0.001 |
Medical history factors | |||
 Age (Mean ± SD) | 51.03 ± 9.67 | 52.27 ± 10.98 | 0.476 |
Age group | |||
 < 40 | 8 (12.9) | 9 (10.2) | 0.705 |
 40 ~ 49 | 21 (33.9) | 33 (37.5) | |
 50 ~ 59 | 21 (33.9) | 24 (27.3) | |
  ≥ 60 | 12 (19.3) | 22 (25.0) | |
BMI (Mean ± SD) | 23.57 ± 3.17 | 23.49 ± 3.11 | 0.879 |
Childbirth (Mean ± SD) | 1.21 ± 0.70 | 1.16 ± 0.69 | 0.663 |
Age of menarche (Mean ± SD) | 13.95 ± 1.77 | 13.47 ± 1.36 | 0.059 |
Age of menopause (Mean ± SD) | 50.58 ± 2.99 | 50.34 ± 2.46 | 0.719* |
Family history of breast, ovarian and pancreatic cancer | |||
 No | 58 (93.5) | 76 (86.4) | 0.189^ |
 Yes | 4 (6.5) | 12 (13.6) | |
Cardiovascular disease as co-morbidity | |||
 No | 54 (87.1) | 64 (72.7) | 0.034 |
 Yes | 8 (12.9) | 24 (27.3) | |
Screen-detected NPBC | |||
 No | 53 (85.5) | 73 (83.0) | 0.677 |
 Yes | 9 (14.5) | 15 (17.0) | |
Bilateral cancer | |||
 No | 60 (96.8) | 85 (96.6) | 0.945^ |
 Yes | 2 (3.2) | 3 (3.4) | |
Imaging features | |||
 MG BI-RADS density | |||
  1 | 5 (8.1) | 9 (10.2) | 0.385# |
  2 | 6 (9.7) | 17 (19.3) | |
  3 | 34 (54.8) | 42 (47.7) | |
  4 | 2 (3.2) | 5 (5.7) | |
  Unknown | 15 (17.0) | 15 (24.2) | |
MG micro-calcification cluster | |||
 No | 23 (37.1) | 44 (50.0) | 0.222# |
 Yes | 24 (38.7) | 29 (33.0) | |
 Unknown | 15 (24.2) | 15 (17.0) | |
MG nodule/mass | |||
 No | 14 (22.6) | 26 (29.5) | 0.509# |
 Yes | 33 (53.2) | 47 (53.4) | |
 Unknown | 15 (24.2) | 15 (17.0) | |
MG lesion BI-RADS | |||
 2, 3 and 4a | 12 (19.4) | 26 (29.5) | 0.274# |
 4b and 4c | 23 (37.1) | 25 (28.4) | |
 5 and 6 | 10 (16.1) | 18 (20.5) | |
 Unknown | 17 (27.4) | 19 (21.6) | |
US lesion BI-RADS | |||
 2, 3 and 4a | 4 (6.5) | 6 (6.8) | 0.340# |
 4b and 4c | 35 (56.5) | 41 (46.6) | |
 5 and 6 | 19 (30.6) | 30 (34.1) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
US max. diameter of tumor (Mean ± SD, cm) | 2.06 ± 0.73 | 2.10 ± 1.02 | 0.785# |
US min. diameter of tumor (Mean ± SD, cm) | 1.33 ± 0.46 | 1.24 ± 0.49 | 0.280# |
US diameter Ratio (min/max) (Mean ± SD) | 0.67 ± 0.15 | 0.64 ± 0.17 | 0.292# |
US aspect ratio | |||
 Normal | 51 (82.3) | 68 (77.3) | 0.414# |
 Abnormal | 7 (11.3) | 14 (15.9) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
US boundary | |||
 Clear | 6 (9.7) | 8 (9.1) | 0.909# |
 Unclear | 52 (83.9) | 74 (84.1) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
US morphology | |||
 Regular | 3 (4.8) | 4 (4.5) | 0.941#^ |
 Irregular | 55 (88.7) | 78 (88.6) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
US hyperechoicity | |||
 No | 28 (45.2) | 37 (42.0) | 0.712# |
 Yes | 30 (48.4) | 45 (51.1) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
US focality | |||
 Unifocal | 41 (66.1) | 54 (61.4) | 0.546# |
 Multifocal | 17 (27.4) | 28 (31.8) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
US blood flow | |||
 Normal | 28 (45.2) | 45 (51.1) | 0.441# |
 Abnormal | 30 (48.4) | 37 (42.0) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
US lymph node | |||
 Normal | 49 (79.0) | 68 (77.3) | 0.807# |
 Abnormal | 9 (14.5) | 14 (15.9) | |
 Unknown | 4 (6.5) | 6 (6.8) | |
Clinicopathological characteristics | |||
 Tumor histology | |||
  IDC-NOS | 56 (90.3) | 83 (94.3) | 0.355 |
  Other | 6 (9.7) | 5 (5.7) | |
pT | |||
 T1 | 38 (61.3) | 60 (68.2) | 0.602^ |
 T2 | 22 (35.5) | 26 (29.5) | |
 T3 | 2 (3.2) | 2 (2.3) | |
Tumor volume (Mean ± SD, cm3) | 3.68 ± 5.46 | 3.97 ± 11.28 | 0.849 |
pN | |||
 N0 | 35 (56.5) | 37 (42.10) | 0.082 |
 N1 | 27 (43.5) | 51 (58.0) | |
Number of positive nodes | |||
 0 | 35 (56.5) | 37 (42.0) | 0.371^ |
 1 | 21 (33.9) | 37 (42.0) | |
 2 | 5 (8.1) | 11 (12.5) | |
 3 | 1 (1.6) | 3 (3.4) | |
TNM stage | |||
 I | 35 (56.5) | 37 (42.0) | 0.082 |
 II | 27 (43.5) | 51 (58.0) | |
Histological grade | |||
 G1 | 2 (3.2) | 10 (11.4) | 0.006 |
 G2 | 48 (77.4) | 74 (84.1) | |
 G3 | 12 (19.4) | 4 (4.5) | |
LVI | |||
 No | 53 (85.5) | 77 (87.5) | 0.721 |
 Yes | 9 (14.5) | 11 (12.5) | |
ER positivity (%) (Mean ± SD) | 87.40 ± 11.20 | 87.70 ± 8.02 | 0.848 |
ER positive level | |||
 Strong (3 +) | 44 (71.0) | 69 (78.4) | 0.298 |
 Mild/Moderate (1–2 +) | 18 (29.0) | 19 (21.6) | |
PR positivity (%) (Mean ± SD) | 53.92 ± 36.49 | 68.83 ± 30.43 | 0.007 |
PR positive level | |||
 High (≥ 20%) | 58 (93.5) | 84 (95.5) | 0.718^ |
 Low (< 20%) | 4 (6.5) | 4 (4.5) | |
PR positive level | |||
 Strong (3 +) | 37 (59.7) | 64 (72.7) | 0.199^ |
 Moderate (2 +) | 20 (32.3) | 21 (23.9) | |
 Mild (1 +) | 5 (8.1) | 3 (3.4) | |
Her2 | |||
 0 | 15 (24.2) | 23 (26.1) | 0.845 |
 1 +  | 23 (37.1) | 35 (39.8) | |
 2 +  | 24 (38.7) | 30 (34.1) | |
Her2 FISH ratio (Mean ± SD) | 1.28 ± 0.38 | 1.22 ± 0.95 | 0.768$ |
Ki67 | |||
 High (≥ 20%) | 54 (87.1) | 40 (45.5) | < 0.001 |
 Low (< 20%) | 8 (12.9) | 48 (54.5) | |