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Table 1 Baseline characteristics of all participants at the time of biopsy collection and characteristics by skin and GI sample collection

From: Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis

 

All participants (N = 19)

Skin KS participants* (N = 10)

GI KS participants* (N = 12)

Age (median in years, IQR)

37 (29, 46)

43 (34, 49)

30 (28.3, 36.1)

Sex (n, %)

   

Cisgender Male

17 (89)

10 (100)

10 (83)

Cisgender Female

1 (5)

 

1 (8)

Transgender Female

1 (5)

 

1 (8)

Race (n, %)

   

White

4 (21)

2 (20)

3 (25)

Black

10 (53)

4 (40)

7 (58)

Hispanic

5 (26)

4 (40)

2 (17)

HIV characteristics

   

HIV co-infection (n, %)

17 (89)

9 (90)

11 (92)

Duration of HIV, median, (median in months, IQR)

95 (5, 147)

117 (5, 145)

97 (26, 107)

CD4 T-cell count, cells/µL (median, IQR)

38 (24, 100)

39 (19, 195)

36 (25, 85)

HIV viral load, copies/mL (median, IQR)

443 (57, 5134)

74 (39, 104)

5134 (552, 47,759)

On antiretroviral therapy (ART) at time of biopsy (n, % of HIV +)

16 (94)

10 (100)

11 (92)

KS characteristics

   

Duration of KS diagnosis (median in months, IQR)

5 (0.9, 32)

5 (1, 38)

10 (1, 16)

Prior therapy for KS or other KAD (n, %)

7 (37)

3 (30)

6 (50)

Concurrent KSHV-associated diseases (n, %)

   

None

5 (16)

5 (30)

3 (8)

KICS

9 (53)

3 (50)

6 (58)

MCD

1 (11)

1 (10)

 

PEL

2 (11)

1 (10)

1 (8)

MCD and PEL

2 (11)

–

2 (17)

KSHV-VL, copies/106 PBMCs (median, IQR)

377 (0, 1798)

90 (0, 728)

1148 (0, 2792)

  1. *Includes 3 participants who provided both skin and GI samples