Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis

Fan, Li-Yuan; Yang, Jing; Liu, Ruo-Yu; Kong, Ying; Guo, Guang-Yu; Xu, Yu-Ming

doi:10.1186/s12967-023-04516-6

Table 2 The names, Moa, and targets of the 30 drugs

From: Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis

Drug name	Moa	Target name
Adenosine	Adenosine receptor agonist	ADORA1\|ADORA2A\|ADORA2B\|ADORA3\|PI4K2A\|PI4K2B\|TRPM4
Anagrelide	Phosphodiesterase inhibitor	PDE3A
Arctigenin	MEK inhibitor	ADIPOR1\|AHR\|CHUK\|MAP2K1
Azacitidine	DNA inhibitor	DNMT1\|DNMT3A
Azacitidine	DNA methyltransferase inhibitor	DNMT1\|DNMT3A
Beclomethasone-dipropionate	Immunosuppressant\|Glucocorticoid receptor agonist	NR3C1\|CYP3A5\|ADGRG3
Benzonatate	Anesthetic—local	SCN5A
Cholic-acid	Bile acid	CES1\|FECH\|PLA2G1B\|ADH1C\|COX1\|COX2\|COX3\|COX4I1\|COX5A\|COX5B\|COX6A2\|COX6B1\|COX6C\|COX7A1\|COX7B\|COX7C\|COX8A\|ESRRG\|FABP6\|GPBAR1
Clofarabine	Ribonucleoside reductase inhibitor	RRM1\|POLA1\|RRM2\|SLC22A8\|POLD1\|POLE\|RRM2B
Cycloheximide	Protein synthesis inhibitor	GSK3B\|RPL3
Epothilone	Tubulin inhibitor	TUBB
Etoposide	Topoisomerase inhibitor	TOP2A\|TOP2B\|CYP2E1\|CYP3A5
Gliquidone	Sulfonylurea	ABCC8\|KCNJ11\|KCNJ10\|KCNJ8
GSK-1070916	Aurora kinase inhibitor	AURKB\|AURKC\|AURKA\|CYP2D6\|CYP3A4
GSK-429286A	Rho associated kinase inhibitor	ROCK1
Imatinib	PDGFR inhibitor\|Bcr-Abl inhibitor\|KIT inhibitor	ABL1\|KIT\|PDGFRA\|BCR\|CSF1R\|PDGFRB\|ABCG2\|CYP2C19\|CYP2C8\|CYP3A5\|DDR1\|NTRK1\|RET
Isoflupredone-acetate	Glucocorticoid receptor agonist	NR3C1
KIN001-244	PDK1 Inhibitor	PDPK1
KN-62	Calcium channel blocker\|Purinergic receptor antagonist	P2RX7\|CAMK2A\|AKT1\|CHEK1\|LCK\|MAPK1\|MAPK11\|MAPK12\|MAPK14\|MAPK8\|PRKCA\|ROCK1\|RPS6KB1\|SGK1
Lupanine	Sodium channel inhibitor	INS
Mitoxantrone	Topoisomerase inhibitor	TOP2A\|PIM1
Nateglinide	Insulin secretagogue	ABCC8\|KCNJ11\|CYP3A4\|INS\|KCNJ10\|PPARG
Nifedipine	Calcium channel blocker	CACNA1C\|CACNA1D\|CACNA1S\|CACNA1F\|CACNA2D1\|CYP3A5\|CACNA1H\|CACNB2\|CALM1\|GLRA1\|GLRA3\|GLRB\|KCNA1\|KCNA5\|NR1I2\|TRPM3
Nimodipine	Calcium channel blocker	CACNA1C\|NR3C2\|CACNA1D\|CACNA1F\|CACNA1S\|AHR\|CACNB1\|CACNB2\|CACNB3\|CACNB4\|CFTR
Oxybenzone	Lipase inhibitor	LIPE
Phenacetin	Cyclooxygenase inhibitor	PTGS1
PLX-4720	RAF inhibitor	BRAF\|KDR
SB-216763	GSK inhibitor	GSK3B\|CCNA2\|CDK2\|GSK3A
SB-756050	G protein-coupled receptor agonist	GPBAR1
Tanaproget	Progesterone receptor agonist	PGR

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ISSN: 1479-5876

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