Fig. 2

Single cell transcriptional landscape of AD, PD, and MS. A Uniform Manifold Approximation and Projection (UMAP) plot of the combined datasets before (right) and after (light) batch correction with Harmony, colored by dataset source. B UMAP representation of the landscape of different CNS cell types. C Dot-plots for the merged snRNA-seq data demonstrates the marker expressions in the different nuclei clusters. D Stacked bar plots of the differing cell-type proportions in the merged dataset. MS_Active (active lesions), MS_CA (chronic active lesions), MS_CI (chronic inactive lesions), MS_NAWM (non-lesioned, normal appearing white matter), MS_ Remyelinating (remyelinating lesions), and Ctrl_NWM (normal white matter)