Fig. 8

Analysis of tumor microenvironment and immunotherapy. A Dotplots of 22 immune cells, with blue dots indicating low-risk group and red dots indicating high-risk group. B Scatter plots showing the relationship between GSDMD and CD4. C Representative images of immunofluorescence and quantitative analysis demonstrated that both GSDMD and CD4 were overexpressed in SKCM tissues (n = 12). D Heatmap showing the expression of eight immune checkpoints in the low- and high-risk groups. E–H The IPS scores between low- and high-risk groups when CTLA-4 or/and PD1 positive. *p < 0.05,***p < 0.001