Fig. 1

GD aggravates cognitive deficits in APP/PS1 mice. A Schematic diagram of the study. APP/PS1 mice were injected with Ad-TSHR289 or Ad-vehicle (n = 32). B–E The serum levels of TT4 (B), TSH (C), TRAb (D), and AST (E) were measured at 34th week after the 1st injection. F Latency to target in the MWM test (n = 6/group). G, H Representative tracings of APP/PS1 mice (G) and GD model mice (H) in the probe trial. I, J The time spent in the target quadrant (I) and the number of crossings the platform (J) in the probe trial. K Swimming speed in the MWM test. L The Y maze spontaneous alternations (n = 6/group). M Novel object recognition test (n = 6/group). F familiar object; N novel object