Fig. 3
Novel pleiotropic loci between lipids and chronic kidney disease identified from cross-trait meta-analysis. A HDL-C and CKD phenotypes; B LDL-C and CKD phenotypes; C TC and CKD phenotypes; D TG and CKD phenotypes. In the circular Manhattan plot, the two circular lanes depict the cross-trait meta-analysis results between lipids traits and CKD phenotypes (blue: eGFR, light blue: CKD). The outermost numbers represent chromosomes 1–22. The red dots represent novel pleiotropic SNPs in the cross-trait meta-analysis (PCPASSOC < 5 × 10–8, 5 × 10–8 < Psingle-trait < 1 × 10–5 (in both traits), and were not in LD (r2 < 0.1) with both single-trait index SNPs). HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TC total cholesterol, TG triglycerides, CKD chronic kidney disease, eGFR estimated glomerular filtration rate