Fig. 1 

The accurate interaction between mitochondria dynamics and mitophagy: A critical bridge in health and disease. Mitochondria play a central role in cellular metabolism and function and are highly dynamic organelles that respond to environmental stimuli, activating fission, fusion, and mitophagy process. Via fission proteins, damaged mitochondria are asymmetrically divided into healthy and impaired organelle degraded via mitophagy and ubiquitin-mediated mitophagy. Moreover, the healthy fraction fuse with other mitochondria, maintain mitochondrial integrity, and regenerate the mitochondrial pool. Deregulation of these mitochondrial pathways leads to several mitochondrial dysfunctions, triggering several disorders, including neurodegenerative disease