Fig. 5

24-h periods of nonadherence is not associated with increased risk of breakthrough seizures. A Calculated odds ratio for the relationship between individual patterns of PER nonadherence in a 24 h window (y-axis) and incidence of a seizure (x-axis). Black: PCBO; Red: PER. Data presented as the odds ratio ± 95% CI. Any CI that does not cross one indicates a significant relationship between a specific meal pattern and seizure incidence as determined by two-tailed Chi-Square analysis. n = 206 seizure events across 12 animals. B Odds ratios computed for the relationship between patterns of acute adherence (y-axis) and the association with a seizure. Data presented as the odds ratio ± 95% CI. Any CI that does not cross one indicates a significant relationship between a pattern of acute nonadherence and seizure incidence as determined by Chi-Square analysis. C Odds ratios computed for the relationship between scenarios of acute nonadherence (y-axis) and the occurrence of a seizure. Data presented as the odds ratio ± 95% CI. Any CI that does not cross one indicates a significant relationship between a pattern of acute nonadherence and seizure incidence as determined by Chi-Square analysis