Fig. 4

Overall degree of seizure control with PER is likely dose dependent. A Average weekly pellet consumption for animals in 100% group (black) and 50% adherent group (teal) during baseline (weeks 1–4) and treatment (weeks 5–8) periods. Data presented as mean ± SEM; n: 100% = 10; 50% = 12 animals). **Significant effect of time (p < 0.01) but no main effect of treatment (p = 0.7120) as determined by mixed effects model with Geisser–Greenhouse correction. B PER plasma concentrations at 1, 2, and 4 weeks following the start of PER chow in 100% (black) and 50% (teal) adherent groups. Data presented as mean ± SEM. *Significant effect if treatment at p < 0.05 as determined by mixed-effects model with Geisser–Greenhouse correction. C Spearman correlations for the relationship between the average pellet consumption and PER plasma concentrations for each animal over the 4-week treatment period in 100% (black) and 50% (teal) adherence groups. Each dot represents single animal. D Spearman correlation for the relationship between the change in seizure frequency (compared to baseline) and average PER plasma concentration for each animal in 100% and 50% adherence groups across the 4-week treatment period. *Significantly different at p < 0.05