Fig. 3

Full adherence to PER results in better seizure control than 50% variable nonadherence. A Representative plot demonstrating relationship between medication schedule (red & black dots) and seizure occurrence (gray dots) in three representative animals in the 100% (top) and 50% (bottom) adherence groups over baseline (week 1–4) and treatment periods (week 5–8). B Cumulative seizure burden in the 4-week baseline (PCBO) and 4-week treatment phases for 50% (teal) and 100% (gray) animals. Seizure burden = total sum of behavioral seizure scores. Data presented as mean ± SEM, PER: n = 10 (100%, gray), 12 (50%, blue); ***Significant time × treatment interaction (p < 0.001) as determined by repeated measures 2-way ANOVA with Geisser–Greenhouse correction. C Average daily seizure burden for individual rats during baseline (open circles) and intervention (closed circles) phase. Each dot represents single animal. Data not statistically significant at p < 0.05 as determined by 2-way ANOVA (top). D Normalized change in seizure burden compared to baseline in 100% (gray) and 50% (teal) adherent rats. Data presented as median ± 95% CI. *p < 0.05 as determined by two-tailed Mann–Whitney test