Fig. 1

Novel formulation methods for drug-in-food generates consistent and uniform PER pellets. A Representative sample of 1 g PCBO pellets formulated in-house using a commercially available tablet press (TDP5, LFA Machines). Each data point represents a single pellet, n = 50 pellets. B, C Representative chromatogram for a 5 ng/ml calibrator sample (B) and subject sample (C). D PER content within and across a random sample of 10 individual food pellets (A–J). Each dot represents the PER content in ¼ of a pellet, with the line indicating mean value for each pellet. No significant differences between inter-pellet PER content as determined by one-way ANOVA