Fig. 7

miR-607 regulates EGFR downstream signaling pathway and mediated cantharidin-indued TNBC cell proliferation inhibition and apoptosis induction. A Protein expression of p-AKT, AKT, p-mTOR, mTOR, p-MEK, MEK, p-ERK and ERK in miR-607-NC or miR-607-Mimic transfected MDA-MB-231 and MDA-MB-468 cells. B Protein expression of p-AKT, AKT, p-mTOR, mTOR, p-MEK, MEK, p-ERK and ERK in miR-607-NC or miR-607-Inhibitor transfected MDA-MB-231 and MDA-MB-468 cells. C Protein expression of p53, Bax, Bcl-2 and Mcl-1 in miR-607-NC or miR-607-Mimic transfected MDA-MB-231 and MDA-MB-468 cells. D Protein expression of p53, Bax, Bcl-2 and Mcl-1 in miR-607-NC or miR-607-Inhibitor transfected MDA-MB-231 and MDA-MB-468 cells. Effects of cantharidin on cell proliferation in miR-607-NC, miR-607-Mimic or miR-607-Inhibitor transfected MDA-MB-231 (E) and MDA-MB-468 (F) cells. Effects of cantharidin on cell apoptosis in miR-607-NC, miR-607-Mimic or miR-607-Inhibitor transfected MDA-MB-231 (G) and MDA-MB-468 (H) cells. Data were expressed as mean ± SEM (n = 3), **p < 0.01