Fig. 8From: Brahma-related gene 1 acts as a profibrotic mediator and targeting it by micheliolide ameliorates peritoneal fibrosisSchematic diagram of MCL’s protection against PD-related peritoneal fibrosis. MCL binds to the conserved N1540 residue of BRG1 and disrupts interaction of BRG1-H3K14ac complex, thereby leading to inhibit TGF-β1-Smad2/3 signaling pathway and fibrotic responses in peritoneal mesothelial cellsBack to article page