Fig. 6

In vivo uptake of ¹²³I-mIBG. A and B Quantitative ex vivo biodistribution data of ¹²³I-mIBG (2–4 MBq) in selected organs at 4 h and 24 h p.i. Statistically significant differences were found between the groups concerning accumulation of the radioligand in tumors; more specifically 2.2 and 3.2-fold higher uptake at 4 h p.i. and 1.9 and 2.2-fold higher uptake at 24 h p.i. in the treated groups (5 and 10 mg/kg, respectively) compared to vehicle. C and D Representative SPECT/CT images of the three treated groups: vehicle (10% DMSO in corn oil), 5 mg/kg CUDC-907 and 10 mg/kg CUDC-907, at 4 h (C) and 24 h (D) after administration of 15–18 MBq ¹²³I-mIBG. The mice were scanned under anesthesia for 90 min (C) and the same mice were scanned 24 h later for 3 h, after euthanasia (D)