Fig. 6

Synergistic si-FTO loading of exosomes effectively protect dopaminergic neuronal death in PD model in vivo. A Confocal microscopy analysis of the distributions of MSC-exo (red)-si-FTO (green) in the striatum of mice PD model. B and C qRT-PCR analysis of FTO and ATM mRNA expressions in the striatum of mice PD model injected with MSC-exo-si-NC or MSC-exo-si-FTO (n = 3). D Western blotting analysis of TH, α-Syn, ATM and FTO protein expressions in the striatum of mice PD model injected with MSC-exo-si-NC or MSC-exo-si-FTO. E Immunofluorescence staining analysis of FTO and TH expressions in the striatum of mice PD model injected with MSC-exo-si-NC or MSC-exo-si-FTO (n = 3). F Immunofluorescence staining analysis of FTO and ATM expressions in the striatum of mice PD model injected with MSC-exo-si-NC or MSC-exo-si-FTO (n = 3). G Immunofluorescence staining analysis of the apoptosis of dopaminergic neurons in the striatum of mice PD model injected with MSC-exo-si-NC or MSC-exo-si-FTO (n = 3).Data are represented as mean ± SD, *represents P < 0.05, **represents P < 0.01