Fig. 2

m6A demethylase FTO significantly increased in PD models in vitro and in vivo. A Heatmap of the m6A-related genes in the striatum of 6 cases of PD patients and 6 cases of healthy persons from GSE54282 datasets. B qRT-PCR analysis of m6A-related genes in the striatum of mice PD model (n = 3). C Western blotting analysis of the indicated protein expressions in the striatum of mice PD model. D IHC analysis of FTO in the striatum of mice PD model (n = 3). E qRT-PCR analysis of m6A-related genes in the cellular PD model (n = 3). F Western blotting analysis of the indicated protein expressions in the cellular PD model. G Immunofluorescence staining analysis of FTO expressions in the cellular PD model (n = 3). Data are represented as mean ± SD, *represents P < 0.05, **represents P < 0.01