Fig. 8

Hyperoside attenuates light-induced dysregulation in the retinal expression of genes essential for photoreceptor morphological and functional integrity. A Heatmap visualization of the representative genes important for photoreceptor morphological and functional integrity revealed by RNA-seq analyses. B–E Real-time qPCR validation of the expression of transcription factors essential for photoreceptor identity (B), the genes involved in photoreceptor homeostasis maintenance (C), the genes expressed in the photoreceptor IS, OS and synapses (D) and the genes important for phototransduction (E). Relative fold change was plotted against NLE. Data were expressed as mean ± SEM (n = 6 per group). **Compared to NLE, P < 0.01; ***compared to NLE, P < 0.001; ^#compared to LE, P < 0.05; ^##compared to LE, P < 0.01; ^###compared to LE, P < 0.001. HYP the light-exposed mice treated with 50 mg/kg hyperoside, LE the light-exposed mice treated with vehicle, NLE the vehicle-treated mice without light exposure