Fig.6

UVR-induced dynamic alterations of lymphatic structure and function regulated by YAP1/Piezo1. A Image of Masson staining. Magnification of microscopic image: 100 × . B Image of VE-CAD (VE-CAD with brown color), C Piezo1 (Piezo1 with brown color), and D YAP1 (YAP1 with brown color) immunochemistry staining in the dermis. Statistics of the area of VE-CAD E, YAP1 F, and Piezo1 G per area in immunochemistry staining. The expression of YAP1 after eight weeks of UVR was the least. When normal tissue progressed to AK, it exceeded normal skin. When AK moved into cSCC, the positive area increased rapidly. Piezo1 represented the opposite trend compared with YAP1. H The trend lines of YAP1, LVs, and Piezo1 value. I Statistics of collagen thickness. J Statistics of the grade of collagen disorganization. Magnification of microscopic image: 100 × . K The potential lymphatic-centered immune microenvironment markers in different skin stages induced by UVR. *, p < 0.05 and **, p < 0.01 indicated a significant difference between groups; ns, no significant difference among groups