Fig. 3

scRNAseq analysis of gingival epithelial and stromal compartments during Metformin treatment. A, B UMAP plot of gingival epithelial cells with heatmap showing subset-specific markers (4280 cells). C, D UMAP plot of gingival stromal cells with heatmap showing subset-specific markers (783 cells). E–H Dot plots depicting GO enrichment terms for BP of epithelial and stromal cell compartments of upregulated genes when treated with Metformin with and without disease induction