Fig. 8

Genetic ablation of caspase-1 prevents HIBD-induced behavioral deficits in mice. a Experimental protocols for model establishment and behavioral tests. b Genetic ablation of caspase-1 (caspase-1^−/−) improved HIBD-induced impairment of the holding power of the right forelimb during the grasping test. c The time spent on the rod was significantly longer in caspase-1^−/− mice following HIBD than in WT mice during the rotarod test. d–f Genetic ablation of caspase-1 (caspase-1^−/−) improved HIBD-induced impairments in spatial learning and memory during the MWM test. In caspase-1^−/− mice, HIBD shortened the latency to find the hidden platform during spatial learning (d) compared with WT mice. Genetic ablation of caspase-1 (caspase-1^−/−) increased the time spent in the target quadrant (e) and the number of entries into the platform zone (f). The data were presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001