Fig. 6

Pharmacological inhibition of caspase-1 by AC-YVAD-CMK prevents HIBD-induced behavioral deficits in rats. a The experimental protocols of HIBD establishment and AC-YVAD-CMK (1 mg/kg, i.p.) injections as well as behavioral tests. b AC-YVAD-CMK treatment increased holding power of right forelimb during the grasping test in rats with HIBD. c AC-YVAD-CMK treatment of rats with HIBD increased the time spent on the rod during the rotarod test. d–f AC-YVAD-CMK treatment alleviated HIBD-induced spatial learning and memory deficits in the MWM test. AC-YVAD-CMK treatment of rats with HIBD shortened the latency to find the hidden platform (d) during training, and increased the time spent in the target quadrant (e) and the number of entries into the platform zone (f) during memory retrieval. The data were presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001