Fig. 5

Inhibiting caspase-1 promotes the dissociation of p97 from GluA1 in cultured primary neurons subjected to OGD. a The expression of p97 in cultured primary neurons remained unchanged following OGD. b, c Co-IP assays were performed 6 h after OGD in cultured neurons. The interaction between p97 and GluA1 was enhanced in neurons subjected to OGD compared to control neurons. AC-YVAD-CMK led to the dissociation of p97 from GluA1. The data were presented as the mean ± SEM. *p < 0.05, ***p < 0.001